Biologists have observed that a key protein that regulates the biological clocks of mammals also regulates glucose production in the liver and that altering the levels of this protein can improve the health of diabetic mice. Their discovery, detailed in this week’s advanced online publication of the journal Nature Medicine, provides an entirely new biochemical approach for researchers to develop therapys for obesity and type 2 diabetes. It also raises the interesting possibility that some of the rise in diabetes in the U.S. and other major industrialized countries could be a consequence of disturbances in sleep-wake cycles from our increasingly around-the-clock lifestyles……..
Treating intensive care patients who develop life-threatening bacterial infections, or septicemia, with insulin potentially could reduce their chances of succumbing to the infection, if results of a new preliminary study can be replicated in a larger study. A paper published online ahead of print in Diabetes Care reports that insulin lowered the amount of inflammation and oxidative stress in study participants who had been injected with a common bacteria, or endotoxin, known as LPS (lipopolysaccharide)……..
About one-third of doctors and their patients with diabetes do not see eye to eye on the most important health conditions to manage, as per a survey by the University of Michigan Medical School. While both groups frequently ranked diabetes and high blood pressure among their top concerns, 38 percent of doctors were more likely to rank high blood pressure as the most important, while only 18 percent of diabetics said it was the most important. Patients were also more likely to prioritize symptoms such as pain and depression……..
A team from the University of Leicester, led by Professor Melanie Davies from the Department of Cardiovascular Sciences and Professor Kamlesh Khunti from the Department of Health Sciences, has developed an easy way for people to assess their risk of having diabetes. Working in partnership with Diabetes UK, the largest diabetes charity in the country, and University Hospitals of Leicester NHS Trust, they have produced the first diabetes risk evaluation that can be used in a multi-ethnic population……..
A Henry Ford Hospital study finds women with type 2 diabetes who take a usually prescribed class of medications to treat insulin resistance appears to be at a higher risk for developing bone fractures. After taking a thiazolidinedione (TZD) for one year, women are 50 percent more likely to have a bone fracture than patients not taking TZDs, as per study results. And those at the greatest risk for fractures from TZD use are women older than 65……..
There is an increased risk of recurring gestational diabetes in pregnant women who developed gestational diabetes during their first and second pregnancies, as per a Kaiser Permanente study appearing online in the American Journal of Obstetrics and Gynecology The study of 65,132 women observed that in comparison to women without gestational diabetes in their first and second pregnancies, women who developed gestational diabetes during their first but not second pregnancies had a 630 percent increased risk for developing gestational diabetes during their third pregnancy. This risk was even more pronounced 25.9-fold in the third pregnancy for women who had gestational diabetes in their first and second pregnancies……..
In two major studies published in Nature Genetics today, scientists use biological understanding to dissect the genetics of diabetes. An international team comprising scientists from more than 100 institutions analysed vast suites of genetic data from more than 100,000 people of European descent to uncover the associations……..